Antofagasta Region Holidays

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Your Antofagasta Region Holiday

Answer the call of adventure with a tailor-made holiday package to Antofagasta Region. Wherever your travels take you and whatever you plan to do, prepare to experience a destination that'll make you truly feel alive. The easiest way to organise your trip to Antofagasta Region is to begin with its most popular cities, which include San Pedro de Atacama, Antofagasta and Historical District. Expedia has flights, hotels, car rentals and more to help you organise your very own customised Antofagasta Region holiday today.

Top destinations in Antofagasta Region

A narrow dirt road lined with buildings and trees, with people walking and a stroller visible.
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San Pedro de Atacama

San Pedro de Atacama
A vast desert landscape with rugged mountains in the background.
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Calama

Calama

Antofagasta Region Essential Information

Language
Spanish
Currency
Chilean pesos
Local Welcome
¡Hola!
Local Goodbye
Adiós
Closest Airport
Calama Airport (CJC)
Population
309,800
Top Sights
Valley of the Moon, Piedra del Coyote Overlook and Arco Iris Valley

Our pick of the best Antofagasta Region Hotel Deals

Diego de Almagro San Pedro de Atacama

Diego de Almagro San Pedro de Atacama

3 out of 5
Toconao 460 San Pedro de Atacama Antofagasta
Fully refundableReserve now, pay when you stay
The price is AU$181 per night from 5 July to 6 July
AU$181
5 July - 6 July
8.2/10 Very good! (393 reviews)
"A gentleman at the front desk was quite rude. We booked two rooms, and neither of them had heating, even though the outside temperature dropped to 2°C at night. In addition, the doors and windows were not properly sealed, making the rooms even colder. The next morning, for our second night’s stay, ..."

Reviewed on 20 May 2026

Diego de Almagro San Pedro de Atacama
Hotel La Casa de Don Tomas

Hotel La Casa de Don Tomas

3 out of 5
Calle Tocopilla Sitio 18 San Pedro de Atacama
Fully refundableReserve now, pay when you stay
The price is AU$303 per night from 7 July to 8 July
AU$303
7 July - 8 July
9.2/10 Wonderful! (423 reviews)
"Excellent property with delicious breakfast, coffee & hot chocolate. Staff were super helpful and friendly. Lunch in the hotel restaurant was delicious and it definitely surprised us. The hotel is located very close to the restaurants & shopping in the town."

Reviewed on 24 June 2026

Hotel La Casa de Don Tomas
Sami Atacama Lodge

Sami Atacama Lodge

3 out of 5
Pasaje Alana No.2 Ayllu De Solcor San Pedro de Atacama
The price is AU$103 per night from 7 July to 8 July
AU$103
7 July - 8 July
8.2/10 Very good! (364 reviews)
"The hotel is a very nice eco friendly hotel indeed with quite nice amenities. The hotel at times is hard to find given the roads that lead into it aren’t easy to navigate. The staff at times aren’t there at reception but overall quite a good stay indeed for the price and note that the area around ..."

Reviewed on 6 Apr 2026

Sami Atacama Lodge
See all 328 properties in Antofagasta Region
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

How much does an Antofagasta Region holiday package cost?
From as low as . Yes, you read that right. Our Antofagasta Region packages are the best way to stretch your budget. Combine your hotels, flights and car rentals and discover this lively destination.
How do I get a cheap travel package to Antofagasta Region?
Our Antofagasta Region holiday packages promise plenty of savings for the savvy traveller. For the best deals, simply bundle your hotel, flights and activities into an affordable package. But impressive bargains are only the start of your next unforgettable adventure. Book with Expedia and you'll have more than 550 airlines and 1 000 000 properties throughout the world to pick from. Whatever your budget, there's a package that's perfect for you.
What are the top hotels in Antofagasta Region?
Have a look at ibis Antofagasta and NH Antofagasta. They're the first choice for lots of travellers to Antofagasta. If San Pedro de Atacama is on your travel itinerary, Park Hotel Calama and Noi Casa Atacama are cosy options.
How far in advance should I book my Antofagasta Region holiday?
It can be tricky to know when is the ideal time to book your trip to Antofagasta Region. But typically the earlier you book, the better the prices. Sometimes, you can reserve your flights and hotels up to a year before your departure date. If you're considering a last-minute getaway, no need to stress! There are fabulous deals featured on Expedia every single day.
What does an Expedia Antofagasta Region travel package include?
From hotels and airfares to rental cars, Expedia can help you shape an Antofagasta Region package that's perfect for you. Holidaying for a week or two? Consider a rental car, hotel and flight bundle. If you're taking a short break, a flight and hotel deal could be more your style. Activities can also be added once you've made your booking. Our holiday packages make it simple to save and plan.
What should I know before booking an Antofagasta Region travel package?
Tailor deals to suit your budget with an Expedia package. Airfares, hotels, rental cars — we're a one-stop shop for all of them. You'll save precious dollars just for bundling your bookings. Whether you're embarking on a skiing adventure or drinking cocktails on a beach, your perfect getaway is just clicks away.
Can I choose my airline with an Antofagasta Region Expedia holiday package?
Expedia has access to more than 550 airline partners worldwide, so you sure can! Simply select your preferred carrier and put together the perfect Antofagasta Region trip.
If I'm not able to travel, can I cancel my Antofagasta Region holiday package?
Whether it's your flight or hotel, you can cancel and rebook it. Locked in your Antofagasta Region holiday package in the last 24 hours? You may be able to make changes at no cost. For bookings older than that, you may be charged a fee by your hotel, airline or car rental company. For further information, visit our Customer Service Portal. We'll help you every step of the way.

Stay near popular Antofagasta Region attractions

Valley of the Moon

9.2/10 (244 reviews)
Treat your eyes to the variety of colors in a deserted valley that looks like a scene from a science fiction movie.
See properties

What to do in Antofagasta Region

Tour to the Valley of the Moon San Pedro de Atacama

Tour to the Valley of the Moon San Pedro de Atacama

AU$52
per adult
94% of travellers recommend
Tour to the Valley of the Moon San Pedro de Atacama
Tatio Geyser - Atacama

Small-Group Tour to Tatio Geysers Machuca Village & Rio Putana wetlands

AU$110
per adult
Small-Group Tour to Tatio Geysers Machuca Village & Rio Putana wetlands
San Pedro de Atacama: Stargazing Experience with Transfer

San Pedro de Atacama: Stargazing Experience

AU$49
per adult
100% of travellers recommend
San Pedro de Atacama: Stargazing Experience
See all activities in Antofagasta Region

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.